Left Ventricular Dysfunction Is Common in MIS-C, But Resolution Usually Occurs Within 6 to 8 Months

June 24, 2021

By Eric Ramos

VIRTUAL -- June 23, 2021 -- Left ventricular (LV) dysfunction and coronary dilations are common in multisystem inflammatory syndrome in children (MIS-C), but these cardiac manifestations do not appear to persist over time, according to a study presented at the Virtual 32nd Annual Scientific Sessions of the American Society of Echocardiography (ASE).

“Left ventricular dysfunction and coronary dilations were commonly diagnosed in the MIS-C patients in our cohort,” said David Barris, MD, Mount Sinai Kravis Children’s Hospital, New York, New York. “However, all patients had resolution of LV dysfunction and ECG changes and most had resolution of coronary dilation.”

The study included 16 patients with MIS-C treated at the Mount Sinai Kravis Children’s Hospital. Electrocardiogram (ECG) and echocardiogram (ECHO) data were collected at initial admission, at 1 month, and at mid-term -- a median of 7 months after admission (range, 6-8.4 months).

“ECG abnormalities seen in children included prolonged QT interval, t-wave abnormalities, and low QRS voltage,” said Dr. Barris. “All ECG abnormalities were resolved by the mid-term visit.”

On initial ECHO, 43.8% of patients had LV dysfunction (LVEF

“At the mid-term visit, left ventricular function was normal in all patients and showed continued improvement,” said Dr. Barris.

On initial ECHO, 18.8% of patients had a coronary artery aneurysm, but at the mid-term follow-up, only 1 patient had a persistent coronary artery aneurysm.

Cardiac MRI was obtained for 7 patients due to elevated troponin levels and reduced LVEF. Follow-up cardiac MRI showed that none of the patients had late gadolinium enhancement, and LVEF was >55% in all patients.

“These data show encouraging mid-term follow-up results, though further longitudinal follow-up is warranted,” said Dr. Barris.

[Presentation title: Longitudinal Outcomes Following Multisystem Inflammatory Syndrome in Children. Poster PC-08]