Managing Organ Dysfunction in the ICU

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Hypercapnia in the Intensive Care Unit: What Do I Need to Know?

Eddy Fan, MD, PhD
8 March 2021

The Role of Extracorporeal Carbon Dioxide Removal (ECCO₂R) in Patients With Acute Respiratory Distress Syndrome (ARDS)

Alain Combes, MD, PhD
8 March 2021

Predicting Risk of Persistent Severe Acute Kidney Injury: The Role of CCL14

John A. Kellum, MD, MCCM
11 November 2020

Exploring the Implications of Early Biomarkers for Persistent Severe AKI

Claudio Ronco, MD
11 November 2020

Acute Kidney Injury: A Significant Complication After Cardiac Surgery

John A. Kellum Jr., MD, MCCM
15 March 2019

Best Practices and Preferred Approaches to Managing CSA-AKI in the ICU

Alexander Zarbock, MD
15 March 2019

The Importance of Managing Fluid Overload in Acute Kidney Injury

Stuart L. Goldstein, MD, FAAP, FASN, FNKF
26 April 2018

Managing Fluid Overload in AKI: Best Practices and Preferred Approaches to RRT

John R. Prowle, MA, MB, BChir, MSc, MD, FFICM, FRCP
26 April 2018

Patient Case Studies

49-year-old man who presented with ischemic chest pain, and then had a witnessed in-hospital cardiac arrest. During the CPR,...

52-year-old man presented to our emergency department with an acute onset of right-sided facial nerve (FN) palsy of House-Brackmann...

4-year-old female with new-onset T-cell acute lymphoblastic leukemia who was found to have a large interventricular septal...

14-year-old girl with SCD whose initial presentation of facial swelling, headaches, jaw pain, and paresthesia mimicked an...

16-year-old female patient presented to the emergency department with a 3-day history of headaches. Initial CT showed no...

In the News

Oral Nirmatrelvir Prevents Progression to Severe COVID-19 in High-Risk, Unvaccinated Outpatients

By Denise Baez Treatment of symptomatic coronavirus disease 2019 (COVID-19) with nirmatrelvir plus ritonavir resulted in a risk of progression to severe COVID-19 that was 89% lower than the risk with placebo, without evident safety concerns, according to a study published in The New England Journal...

Subcutaneous Monoclonal Antibodies Reduce Hospitalisation, Death in High-Risk Outpatients With Mild to Moderate COVID-19 Symptoms

By Denise Baez Subcutaneously administered casirivimab and imdevimab was associated with reduced hospitalisation and death in high-risk outpatients with mild to moderate coronavirus disease 2019 (COVID-19) symptoms when compared with no treatment, and showed similar outcomes compared with...

Myopericarditis Following COVID-19 Vaccination Is Rare, International Study Finds

The overall risk of myopericarditis following coronavirus disease 2019 (COVID-19) vaccination is very low, affecting 18 people per million vaccine doses, according to a study published in The Lancet Respiratory Medicine. Kollengode Ramanathan, MD, National University Hospital, Singapore, and...

Omicron Less Severe Than Delta for Children Aged Younger Than 5 Years

The incidence rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with Omicron variant was 6 to 8 times that of Delta variant in children aged younger than 5 years, but severe clinical outcomes were less frequent than with Delta variant, according to a study published in...

Convalescent Plasma Can Be Effective for COVID-19 if Given Early

Convalescent plasma is an effective and safe option as an early outpatient coronavirus disease 2019 (COVI-19) treatment, according to a study published in The New England Journal of Medicine. The research showed that high-titre convalescent plasma, when administered to outpatients within 9 days...

Conference Reports

Epinephrine Dosing Intervals Are Associated With Paediatric Cardiac Arrest Outcomes

By Erika Pimentel

VIRTUAL -- April 20, 2022 -- Shorter epinephrine dosing intervals were associated with favourable outcomes in paediatric patients requiring CPR due to an in-hospital cardiac arrest, according to a study presented at the 51st Critical Care Congress, the Annual Meeting of...

Blood Test Accurately IDs Patients at Low Risk of Sepsis in Emergency Department

By Eric Ramos

VIRTUAL -- March 30, 2022 -- A whole blood, multiplex host mRNA expression metric outperformed established risk prediction systems and biomarkers in identifying low-risk patients presenting to the emergency department with suspected infections or sepsis who can safely be...

Difficulty Breathing More Ominous Than Chest Pain Among Patients With Myocardial Infarction

By Ed Susman

VIRTUAL -- March 21, 2022 -- A nationwide study of patients presenting to the hospital due to a possible myocardial infarction (MI) indicates that a patient complaining of shortness of breath may have a worse outcome than patients who have chest pain as their main symptom,...

Failure to Reduce High Blood Pressure After Endovascular Therapy Linked to Poorer Outcomes

By Nancy Melville

VIRTUAL -- February 14, 2022 -- Patients with acute ischaemic stroke and high blood (BP) pressure following successful endovascular therapy show poorer outcomes if blood pressure is not lowered soon after the procedure, according to a study presented at the 2022...

Systemic Amyloidosis in Older Adults Linked to Increased Intracranial Haemorrhage Risk

By Nancy Melville

VIRTUAL -- February 14, 2022 -- Systemic amyloidosis in older patients is associated with a significant increase in the risk of intracranial haemorrhage, according to a study presented at the 2022 International Stroke Conference (ISC).

“In a...

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American Journal of Cardiology

Unstable Angina Pectoris With Myocardial Injury Versus Myocardial Infarction in the Era of High-Sensitivity Cardiac Troponin

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A case of fatal myxedema coma with electrocardiogram Osborne J-wave in a patient initially diagnosed with hypothyroidism

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BMJ Open

Clinical and imaging characteristics of patients with COVID-19 predicting hospital readmission after emergency department discharge: a single-centre cohort study in Italy

Maria Giulia Galli, Olivera Djuric, Giulia Besutti, Marta Ottone, Lucia Amidei, Lee Bitton, Carlotta Bonilauri, Luca Boracchia, Sergio Campanale, Vittoria Curcio, Davide Maria Francesco Lucchesi, Cesare Salvatore Mulas, Francesca Santi, Anna Maria Ferrari, Paolo Giorgi Rossi, Francesco Luppi, Reggio Emilia COVID-19 Working Group

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Use and diagnostic value of liver enzyme tests in the emergency department and subsequent heart failure diagnosis: a retrospective cohort study

Elena Vasti, Jeffrey A Tabas, Ari Hoffman, Mark Pletcher

BMCB Emergency Medicine

Predictive performances of ALS and BLS termination of resuscitation rules in out-of-hospital cardiac arrest for different resuscitation protocols

Yu-Yuan Lin, Yin-Yu Lai, Hung-Chieh Chang, Chien-Hsin Lu, Po-Wei Chiu, Yuh-Shin Kuo, Shao-Peng Huang, Ying-Hsin Chang, Chih-Hao Lin