Managing Organ Dysfunction in the ICU

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The Importance of Managing Fluid Overload in Acute Kidney Injury
Stuart L. Goldstein, MD, FAAP, FASN, FNKF
26 April 2018
Managing Fluid Overload in AKI: Best Practices and Preferred Approaches to RRT
John R. Prowle, MA, MB, BChir, MSc, MD, FFICM, FRCP
26 April 2018

Coming Soon

Understanding Hypercapnia in Critically Ill Patients: Using Extracorporeal CO2 Removal (ECCO2R) to Optimise Outcomes

Patient Case Studies

59-year-old female with acute erythroid leukemia received a peripheral blood stem cell transplant from her HLA-haploidentical...

58-year-old female with a past history of a pituitary adenoma resected two years prior to admission who developed polymorphic...

58-year-old man presented to the emergency department with acute respiratory failure and altered mental status. He was on...

46 year old female patient, who presented with complaints of severe headache and right sided weakness. Examination revealed...

73-year-old Asian gentleman with underlying hypertension, hyperlipidaemia, chronic renal failure, and history of chronic...

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In the News

Machine Learning Tool Predicts Likelihood of Acute Myocardial Infarction
By Denise Baez In a large, international multicentre study of more than 11,000 patients with suspected myocardial infarction (MI), researchers successfully used machine learning to accurately predict the likelihood of a definite MI diagnosis. The tool can be used to individualise the risk...
Pharmacists in the ER Speed Delivery of Coagulation Drug to Bleeding Patients
A pharmacist at the bedside of patients who present to the emergency department with life-threatening bleeding or need for an emergent procedure decrease time to 4-factor prothrombin complex concentrate (PCC) administration, according to a study published in the Journal of Emergency Medicine. For...
Giving Trauma Patients Arginine Vasopressin Reduces Blood Transfusions by Half
Giving trauma patients with haemorrhagic shock the hormone arginine vasopressin (AVP) reduces the volume of blood products required to stabilise them by half, according to a study published in JAMA Surgery. The findings suggest that administering AVP to trauma patients with severe bleeding could...
Blood Test Detects Concussion, Subconcussive Injuries in Children and Adults
In one of the largest studies of its kind, researchers are making new progress in finding ways to detect a traumatic yet sinister brain injury -- and getting closer to preventing further damage. “A unique feature of this study is that it includes patients who hit their heads but have no symptoms...
Women More Likely to Have Typical MI Symptoms
Typical symptoms are more common and have greater predictive value in women than in men with myocardial infarction (MI), according to a study published in the Journal of the American Heart Association. The finding puts into question a long-held medical myth that women tend to suffer atypical MI...
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Conference Reports

Cardiac Troponin Cut-Offs ID Low-Risk Patients With Suspected Acute Coronary Syndrome

By Frances Morin

PARIS -- September 2, 2019 -- Use of a high-sensitivity cardiac troponin I assay and key risk stratification thresholds in patients suspected of having acute coronary syndrome is highly effective in identifying low-risk patients, allowing for the avoidance of unnecessary...

Asthma Therapy Reduces Hospital/Emergency-Room Visits for Severe Asthma

By Alex Morrisson

DALLAS -- May 24, 2019 -- Asthma exacerbations requiring hospitalisation were reduced 79% in patients taking tezepelumab compared with placebo, according to an exploratory analysis of the phase 2b PATHWAY study presented at the 2019 Annual Meeting of the American...

Omadacycline Effective, Safe for Pneumonia and Skin Infections in Patients With Renal Insufficiency

By Shazia Qureshi

AMSTERDAM, the Netherlands -- April 16, 2019 -- Omadacycline appears to be effective and safe in patients with community-acquired bacterial pneumonia (CABP) or acute bacterial skin and skin structure infection (ABSSSI) who also have mild or moderate renal insufficiency,...

Chest X-Ray Does Not Have Diagnostic Value in Patients With Fever, No Respiratory Signs or Symptoms

By Shazia Qureshi

AMSTERDAM, the Netherlands -- April 16, 2019 -- A study assessing emergency department patients presenting with fever or elevated C-reactive protein (CRP) suggests that chest x-ray might not be a useful diagnostic if no other signs or symptoms of pneumonia are present....

Angiotensin II Helps Patients With Catecholamine-Resistant Distributive Shock Achieve Target Mean Arterial Pressure

By Charles Grey

BRUSSELS, Belgium -- March 25, 2019 -- In patients with catecholamine-resistant distributive shock and baseline mean arterial pressure (MAP)

Results of the phase 3 Treatment of High-Output Shock (ATHOS-3) trial, presented here at the 39th International Symposium on...

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Recently Published

Abstracts in Multiple Sclerosis

BMJ Case Reports
High-pressure chemical injection injury to the hand: usually underestimated injury with major consequences
Raman Sharma, Jerry R John, Ramesh Kumar Sharma
American Journal of Emergency Medicine
Use of meropenem to treat valproic acid overdose
Diane Dreucean, Kevin Beres, Afton McNierney-Moore, Dante Gravino
Journal of Paediatrics and Child Health
Appendicitis or non-specific abdominal pain in pre-school children: When to request abdominal ultrasound?
Marcos Prada-Arias, Javier Gómez-Veiras, José L Vázquez, Ángel Salgado-Barreira, Margarita Montero-Sánchez, José R Fernández-Lorenzo
Annals of Emergency Medicine
Demystifying Lactate in the Emergency Department
Gabriel Wardi, Jessica Brice, Matthew Correia, Dennis Liu, Michael Self, Christopher Tainter
World Neurosurgery
Nail-Gun Injury of the Spine:Case Report and Review of the Literature
Geng Xiang, Zixiang Wu, Xiong Zhao, Xiaolei Zhao, Yafei Feng
See more >>

Full-Text Articles

BMJ Open
A comprehensive validation of very early rule-out strategies for non-ST-segment elevation myocardial infarction in emergency departments: protocol for a multicentre prospective cohort study
Masafumi Tada, Hiroyuki Azuma, Naoki Yamada, Ken-Ichi Kano, Hideya Nagai, Shigenobu Maeda, Hiroshi Ishida, Takahiko Aoyama, Ryota Okada, Takahisa Kawano, Taketsune Kobuchi, Hiroyasu Uzui, Hideyuki Matano, Hose Iwasaki, Koji Maeno, Yoshimitsu Shimada, Hiroyuki Yoshida, Masaki Ando, Yoshimasa Murakami, Naotsugu Iwakami, Sanae Kishimoto, Taku Iwami, Hiroshi Tada, Andrew Chapman, Nicholas Mills, Hiroyuki Hayashi, Toshi A Furukawa, Norio Watanabe
BMJ Open
Early point-of-care focused echocardiographic asystole as a predictive factor for absence of return of spontaneous circulatory in out-of-hospital cardiac arrests: a study protocol for a prospective, multicentre observational study
François Javaudin, Philippe Pes, Emmanuel Montassier, Arnaud Legrand, Aline Ordureau, Christelle Volteau, Idriss Arnaudet, Philippe Le Conte
BMJ Open
Glucocorticoids for acute urticaria: study protocol for a double-blind non-inferiority randomised controlled trial
Nicolas Javaud, Angele Soria, Maxime Maignan, Ludovic Martin, Vincent Descamps, Olivier Fain, Laurence Bouillet, Frederic Berard, Karim Tazarourte, Pierre-Marie Roy, Jean-Paul Fontaine, Martine Bagot, Mehdi Khellaf, Helene Goulet, Frederic Lapostolle, Enrique Casalino, Marie-Sylvie Doutre, Cedric Gil-Jardine, Frederic Caux, Olivier Chosidow, Dominique Pateron, Eric Vicaut, Frederic Adnet
BMJ Open
Timing of respiratory virus molecular testing in emergency departments and its association with patient care outcomes: a retrospective observational study across six Australian hospitals
Nasir Wabe, Ling Li, Maria R Dahm, Robert Lindeman, Ruth Yimsung, Kate Clezy, Judith Thomas, Wayne Varndell, Johanna Westbrook, Andrew Georgiou
Emergency Medicine Journal
Exploring the characteristics, acuity and management of adult ED patients at night-time
Rebecca Simpson, Susan Croft, Colin O'Keeffe, Richard Jacques, Tony Stone, Nisar Ahmed, Suzanne M Mason
See more >>

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Continuously updated news and conference coverage.


Helpful resources for your practice and patients.


Resource Library

CRRT Online: Acute Therapy Resources

Cardiac and Vascular Surgery–Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group

Nadim MK et al. J Am Heart Assoc. 2018;7:e008834

KDIGO Clinical Practice Guideline for Acute Kidney Injury

Kidney Int Suppl. 2012;2:1-128

Fluid Management for the Prevention and Attenuation of Acute Kidney Injury

Prowle JR et al. Nat Rev Nephrol. 2014;10:37-47

Fluid Management in Acute Kidney Injury

Goldstein SL. J Intensive Care Med. 2014;29:183-189

Indications and Management of Mechanical Fluid Removal in Critical Illness

Rosner MH et al. Br J Anaesth. 2014;113:764-771

Recovery After Acute Kidney Injury

Kellum JA et al. Am J Respir Crit Care Med. 2017;195:784-791

Prevention of Cardiac Surgery–Associated AKI by Implementing the KDIGO Guidelines in High-Risk Patients Identified by Biomarkers: The PrevAKI Randomised Controlled Trial

Meersch M et al. Intensive Care Med. 2017;43:1551-1561

Effect of Remote Ischaemic Preconditioning on Kidney Injury Among High-Risk Patients Undergoing Cardiac Surgery: A Randomised Clinical Trial

Zarbock A et al. JAMA. 2015;313:2133-2141

Strategies for the Optimal Timing to Start Renal Replacement Therapy in Critically Ill Patients With Acute Kidney Injury

Bagshaw SM, Wald R. Kidney Int. 2017;91:1022-1032

Early vs Late Initiation of Renal Replacement Therapy Impacts Mortality in Patients With Acute Kidney Injury Post-Cardiac Surgery: A Meta-Analysis

Zou H et al. Crit Care. 2017;21:150