Managing Organ Dysfunction in the ICU

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Predicting Risk of Persistent Severe Acute Kidney Injury: The Role of CCL14

John A. Kellum, MD, MCCM
11 November 2020

Exploring the Implications of Early Biomarkers for Persistent Severe AKI

Claudio Ronco, MD
11 November 2020

Hypercapnia in the Intensive Care Unit: What Do I Need to Know?

Eddy Fan, MD, PhD
8 May 2019

The Role of Extracorporeal Carbon Dioxide Removal (ECCO₂R) in Patients With Acute Respiratory Distress Syndrome (ARDS)

Alain Combes, MD, PhD
8 May 2019

Acute Kidney Injury: A Significant Complication After Cardiac Surgery

John A. Kellum Jr., MD, MCCM
15 March 2019

Best Practices and Preferred Approaches to Managing CSA-AKI in the ICU

Alexander Zarbock, MD
15 March 2019

The Importance of Managing Fluid Overload in Acute Kidney Injury

Stuart L. Goldstein, MD, FAAP, FASN, FNKF
26 April 2018

Managing Fluid Overload in AKI: Best Practices and Preferred Approaches to RRT

John R. Prowle, MA, MB, BChir, MSc, MD, FFICM, FRCP
26 April 2018

Patient Case Studies

38-year-old man with an atypical complex elbow dislocation. He was successfully treated by stabilizing the medial epicondyle...

13-year-old girl with cutaneous lesions and multifocal granulomatous encephalitis. The patient underwent a series of tests...

3-year-old boy who presented for tachypnea and chest pain with cough, rhinorrhea, and congestion. He was discharged with...

20-year-old patient requiring initial stabilization at a referring critical access emergency department with continuation...

Silver-Russell syndrome is a rare genetic disorder, occurring in ∼1/50,000 to 1/100,000 births. Anomalies of the urogenital tract such as hypospadias and cryptorchidism can be present. Testicular...

In the News

Study Shows a Dose-Response Association Between Cigarette Pack-Years, Adverse COVID-19 Outcomes

By Denise Baez Cumulative exposure to cigarette smoke is an independent risk factor for hospital admission and death from coronavirus disease 2019 (COVID-19), according to a study published in JAMA Internal Medicine. In a study of 7,102 patients who tested positive for severe acute respiratory...

Rapid Increase of a SARS-CoV-2 Variant With Multiple Spike Protein Mutations Observed in the United Kingdom

By Denise Baez A novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant has been identified in the United Kingdom, and preliminary analysis suggests that the variant is significantly more transmissible than previously circulating variants, according to a Threat Assessment Brief...

FDA Issues Emergency Use Authorisation for Second COVID-19 Vaccine

The US Food and Drug Administration (FDA), on December 18, 2020, issued an emergency use authorisation (EUA) for the second vaccine for the prevention of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The EUA allows Moderna’s mRNA-1273...

ACAAI Updates Guidance Related to Risk of Allergic Reactions With mRNA COVID-19 Vaccines

The American College of Allergy, Asthma, and Immunology (ACAAI) has issued guidance for physicians and other providers related to the risk of an allergic reaction following vaccination with an mRNA-based coronavirus disease 2019 (COVID-19) vaccine. ACAAI’s recommendations are in line with guidance...

Early Tracheostomy Noninferior to Late Tracheostomy in Patients With COVID-19

By Denise Baez Among patients with coronavirus disease 2019 (COVID-19) who were treated during the first 2 months of the pandemic in New York City, early tracheostomy was noninferior to late tracheostomy, and was associated with improvement in some outcomes, according to a study published in JAMA...

Conference Reports

Sickle Cell Disease Confers Higher COVID-19 Mortality, Hospitalisation Risk

By Walter Alexander

NEW YORK -- December 8, 2020 -- Compared with the general black population in California, black patients with sickle cell disease who became infected with coronavirus disease 2019 (COVID-19) have higher rates of COVID-19 death, according to a study presented at the...

D-Dimer Levels Alone Not Enough to Initiate Anticoagulation in Hospitalised Patients With COVID-19

By Eric Ramos

CHICAGO -- November 19, 2020 -- Deep venous thrombosis (DVT) was frequently diagnosed in patients hospitalised with coronavirus disease 2019 (COVID-19) who underwent imaging due to elevated D-Dimer levels; however, there was considerable overlap of peak D-Dimer values
...

Majority of Patients With Asthma Do Not Receive Guideline-Directed Therapy in the Emergency Department

By Ed Susman

WEST PALM BEACH, Fla -- November 19, 2020 -- When patients who are experiencing asthma exacerbation present at the emergency department, they frequently do not receive guideline-directed treatment, education, or medication, according to a study presented at the Virtual 2020...

Risk of COVID-19 Infection Not Higher in Patients With Cancer Receiving Immunotherapy

By Eric Ramos

CHICAGO -- November 10, 2020 -- Treatment with immune checkpoint inhibitors does not appear to be a risk factor for contracting coronavirus disease 2019 (COVID-19), according to a study presented at the Virtual 35th Annual Meeting of the Society of Immunotherapy of Cancer (...

Adding Dantrolene Sodium Suspension to Body Cooling Improves Outcomes in Patients With Exertional Heat Stroke

By Louise Gagnon

OTTAWA, Ontario -- November 3, 2020 -- The adjunctive use of dantrolene sodium suspension to treat exertional heat stroke, in addition to body cooling, improved recovery of loss of consciousness, according to research presented at the 2020 Virtual Meeting of the American...

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Emergency hernia surgery at a high-volume tertiary centre: a 3-year experience

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Deep vein thrombosis with pulmonary thromboembolism in a case of severe COVID-19 pneumonia

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Development and Validation of a Simplified Probability Assessment Score Integrated With Age-Adjusted d-Dimer for Diagnosis of Acute Aortic Syndromes

Fulvio Morello, Paolo Bima, Emanuele Pivetta, Marco Santoro, Elisabetta Catini, Barbara Casanova, Bernd A Leidel, Alexandre de Matos Soeiro, Thomas Nestelberger, Christian Mueller, Stefano Grifoni, Enrico Lupia, Peiman Nazerian

Full-Text Articles

Journal of the American Heart Association

In Search of an Optimal Subset of ECG Features to Augment the Diagnosis of Acute Coronary Syndrome at the Emergency Department

Zeineb Bouzid, Ziad Faramand, Richard E Gregg, Stephanie O Frisch, Christian Martin-Gill, Samir Saba, Clifton Callaway, Ervin Sejdić, Salah Al-Zaiti

BMC Infectious Diseases

Clinical physiological parameters for the prediction of gram-negative bacterial infection in the emergency department

Chan-Peng Hsu, Hsin-Yu Chen, Wei-Lung Chen, Jiann-Hwa Chen, Chien-Cheng Huang, Po-Han Wu, Jui-Yuan Chung

Respiratory Research

Ruling out COVID-19 by chest CT at emergency admission when prevalence is low: the prospective, observational SCOUT study

Ulf Teichgräber, Amer Malouhi, Maja Ingwersen, Rotraud Neumann, Marina Reljic, Stefanie Deinhardt-Emmer, Bettina Löffler, Wilhelm Behringer, Jan-Christoph Lewejohann, Andreas Stallmach, Philipp Reuken

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Foodborne botulism presenting as small bowel obstruction: a case report

Alberto Friziero, Cosimo Sperti, Gianfranco Da Dalt, Nicola Baldan, Gianpietro Zanchettin, Pasquale Auricchio, Laura Gavagna, Andrea Grego, Giulia Capelli, Stefano Merigliano

Journal of Medical Case Reports

Ovarian borderline tumor presenting as ovarian torsion in a 17-year-old patient: a case report

Ana Patrícia Vicente, Andrea Sousa Gomes, Ligita Jokubkiene, Povilas Sladkevicius